The degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590.
نویسندگان
چکیده
The microbial degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590 was studied, and two major products were isolated and identified as 7 alpha, 12 beta-dihydroxyandrosta-1,4-diene-3,17-dione and 7 alpha, 12 alpha-dihydroxy-3-oxopregna-1,4-diene-20-carboxylic acid. Four minor products were isolated and evidence is given for the following structures: 7 alpha, 12 alpha-dihydroxyandrosta-1,4-diene-3,17-dione, 12 beta-hydroxyandrosta-1,4,6-triene-3,17-dione, 7 alpha, 12 beta, 17 beta-trihydroxyandrosta-1,4-dien-3-one and 7 alpha, 12 alpha-dihydroxy-3-oxopregn-4-ene-20-carboxylic acid. The significance of the production of the steroid products is discussed, along with the possible enzymic mechanisms responsible for their production.
منابع مشابه
The degradation of cholic acid by Pseudomonas sp. N.C.I.B. 10590 under anaerobic conditions.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 184 3 شماره
صفحات -
تاریخ انتشار 1979